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8-week-old SD rats, 3-week-old WKY rats and 3-week-old SHR rats were respectively purchased from Charles River Laboratories (Montreal, Quebec, Canada)

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The same research group also published a study in older adults with HIV showing similar benefits, including reduced oxidative stress and improved mitochondrial fatty acid oxidation (Kumar et al., Antioxidants, 2020) [30]

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A frequently cited example, discussed in more detail later in this article, is a study by Maric et al., 2022, which examined NAD+ metabolism in genetically engineered mouse models predisposed to cancer and reported that nicotinamide riboside (NR) availability influenced cancer metabolism in certain contexts. It is important to define what such findings represent