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This change, while seemingly minor, altered the pharmacological profile to favor central MC4R-mediated sexual function effects while reducing some peripheral activities

Therefore, pale skin was desired, and the use of bleaching creams or white facial makeup, sometimes with toxic ingredients, was not uncommon

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Ference BA, Graham I, Tokgozoglu L, Catapano AL (2018) Impact of lipids on cardiovascular health: JACC health promotion series