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The poly-dipeptides derived from C9ORF72 hexanucleotide expansions exhibit high affinity for mitochondrial proteins, thereby impairing mitochondrial structural integrity and intracellular transport dynamics, as well as Ca 2+ uptake and ATP synthesis (Yu et al., 2020)

Patients know exactly what to do on day 1 and exactly what we are checking at day 90

medium-depth peels (TCA above 30 to 50%) reach the upper reticular dermis

Journal of Cell Science, 112(Pt 11), 17211732

These patients presented a disrupted 24h circadian rhythm, and a reduction of sleep time and quality, that were reversed after the administration of melatonin (86, 87)