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Prostaglandin E2 was obtained from Cayman Chemical Co
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Some patients need progressively smaller cuts, liquid formulations, or other precision methods to make the taper tolerable

These peptides, typically of low molecular weight and enriched in specific motifs such as Pro-Hyp and Gly-Pro, have been shown to interact with key biological targets and modulate physiological processes at the molecular level [69,70,71,72]

GraphPad Prism 8.02 (GraphPad Software) was employed to perform statistical analysis
