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This method allows for targeted delivery of bioactive molecules, circumventing the limitations associated with systemic or topical treatments

In light of this, the present review is intended to fully delineate the entire scope of cancer chemoprevention, and primarily focuses on various aspects of cancer chemoprevention based on natural compounds, specifically focusing on the mechanism of action of natural compounds in cancer prevention, and discussing in detail how they exert cancer prevention effects by affecting classical signaling pathways, immune checkpoints, and gut microbiome

Finally, the intensity ratio (r int ) is calculated as the quotient of signal intensity at the peak position (I peak ) divided by the mean signal intensity in the surrounding medium (I out )