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Moreover, Tet3-KD neurons or Tetrodotoxin-induced decreases in Tet3 expression exhibited increased CpG methylation at the BDNF promoter IV region, whereas bicuculline-induced increases in Tet3 expression were shown to be associated with decreased methylation at the same region, supporting a pivotal role of Tet3 in regulating gene expression in response to global synaptic activity changes [54]
Mol Biol Evol 29: 101111, 2012
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Other potential complications include thrombosis occurring due to a sudden increase in platelet counts, bleeding during or after surgery, and a long-term increased risk of vascular events [73, 74]
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