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Seefelder, W

In preparation for this experiment, the Conboys have invested years in miniaturizing the technology for blood transfusions, so that mice can be subjected to the same procedures that are commonplace in human hospitals

ATP-dependent Transport by MRP1 Transport by MRP1 (and other ABC transporters) is powered by the binding and hydrolysis of ATP, which facilitate the necessary protein conformation changes that enable solute translocation to occur

doi:10.1002/hep.1840090324

This quick clearance limits the delivery of therapeutic payload over the long period of time for which the mucoadhesion is designed, reducing the bioavailability of inhaled therapeutics 145