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According to Digestive System and Nutrient Needs of Meat Goats by Purdue Extension, Sulfur produces thiamine-like compounds called analogs that decrease the absorption of thiamine in the rumen. There are many possible sources of excessive sulfur, including: water sources, alfalfa, cruciferous plants, distillers grains, and corn, sugar beet, and sugar cane byproducts

However, several like Semaglutide and Tirzepatide for weight loss and diabetes have FDA-approved applications and are widely used under physician supervision

Implications for inhibitor specificity and drug design