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[114] The estimated median effective dose (ED 50 ) for SERT occupancy hence was 98.1 mg, which was associated with a plasma tramadol level of about 330 ng/mL (1,300 nM)

The statistical imputation recodes missing functional status data to a likely value had the status been assessed, whereas the current imputation approach implemented in existing function outcome measures recodes missing data to the lowest functional status

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Gentle pressure afterwards usually settles it