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Administering these vitamins via injection bypasses gastrointestinal absorption barriersuseful for patients with pernicious anemia, post-gastrectomy states, chronic metformin or acid-suppressing therapy that impairs B12 absorption, or conditions that reduce intestinal uptake

The enteric coating provides additional protection, ensuring release in the small intestine where absorption occurs

In two trials employing 1000 g/day oral vitamin B 12 , there was no clinically relevant difference in vitamin B 12 levels when compared with IM vitamin B 12