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141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2

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It has also been used successfully for the treatment of acute respiratory distress syndrome at a dose of 150mg/kg on day one followed by 50mg/kg for 3 days, with efficacy in part determined by GST polymorphisms

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