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Powers SK, Goldstein E, Schrager M, Ji LL

Glutathione peroxidase 4 (GPx4), is the only enzyme in cells that can reduce lipid peroxides to normal phospholipid molecules, its activity is crucial for maintaining normal cell function and ferroptosis [74]

This is in line with a study defining an IL-10/TGF- signaling loop between activated astrocytes and microglia that limits CNS inflammation (98)

In addition to metabolism, various environmental factors contribute to the generation of free radicals in skin cells, such as exposure to UV radiation, pollution, or tobacco smoke

In addition to IGF-I, several other factors (see Box 3) also contribute to muscle maintenance and adaptation