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Established low ranges are often too low, and researchers have found that normal-low B12 levels have been associated with neurological symptoms such as difficulty balancing, memory lapses, depression, mania, fatigue, and even psychosis

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Also poorly understood is the potential relationship that may exist between hepatocyte swelling in response to amino acids, the obligatory KCC-dependent K + /Cl extrusion, the resulting reduction in [Cl ] i and glycogen synthesis via activation of the Cl -dependent enzyme glycogen synthase phosphatase (Meijer et al., 1992)