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Using the same assay, a similar dimerization pattern was observed in response to different doses of R1881 in LNCaP cells (Fig

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It is also important to note that states of GH-excess, such as acromegaly, are associated with muscle weakness and fatigue (Flitsch, Spitzner and Ludecke, 2000), suggesting that chronically elevated levels of GH or IGF-I have a deleterious effect on muscle

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