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During ferroptosis, acyl-CoA synthetase long-chain family member 4 (ACSL 4), lysophosphatidylcholine acyltransferase 3 (LPCAT 3), and arachidonic acid 15-lipoxygenase (ALOX 15) are required for lipid peroxidation

Thus, long-term supplementation of an aging population with adequate doses of melatonin may help to improve the health status of the targeted group of elderly people

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Finally, the increased (the present ischemia/reperfusion study) or decreased (inferior caval vein occlusion study) (Vukojevic et al., 2018) expression of Vegfr2 that coincides with continuously increased Nos3 expression may reflect particularities of the organization of the response in the hippocampus after bilateral carotid artery ligation during reperfusion and ischemia in rats with occluded inferior caval veins (Vukojevic et al., 2018)