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Med 10, 1191354 (2023)

10.1126/science.1083516 37

A microinfusion serum that suits a 38-year-old with early fine lines is not the same protocol as one that suits a 46-year-old with melasma

Raza-IqbalSTanakaTAnaiMInagakiTMatsumuraYIkedaKet alTranscriptome analysis of K-877 (a novel selective PPARalpha modulator (SPPARMalpha))-regulated genes in primary human hepatocytes and the mouse liver

Given these findings, clinicians should be alert to biliary system AEs in patients receiving ICIs, especially those on combination therapy, presenting with abdominal pain and jaundice, and consider imaging and liver function tests for early diagnosis