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First-in-human ultrasound molecular imaging with a VEGFR2-specific ultrasound molecular contrast agent (BR55) in prostate cancer: a safety and feasibility pilot study

In another work, the same authors showed that SAC (300 mg/Kg) reduced the size of infarct area after 2 h occlusion and 22 h reperfusion, prevented neuronal cell death in CA1 region and inhibited the activity of ERK induced by focal ischemia in a middle cerebral artery occlusion model in gerbils, while in vitro exerted scavenging activity on peroxynitrite [28]

PLoS One 7:e38727

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HEPES-buffered (25 mM, pH 7.4) DMEM high glucose (25 mM, pH 7.4) was overlaid and plates were incubated in 37 C warm Operetta plate reader (Perkin Elmer) during the whole assay duration