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St Jude Childrens Research hospital have demonstrated an increase in the 3-year OS and EFS in non chemo-refractory recipients receiving CD45RA-depleted grafts (78.9% and 77.7%, respectively) compared with historic T-cell depleted haploHSCT cohorts (46.7% and 42.7%, respectively, p = 0.004, and 0.003)

AKAP12 is a new and effective scaffold protein, which plays an important role in protein kinase C, protein kinase A, cyclin, F-actin, and other key signal factors (28)

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