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The absolute count of double-negative B cells also significantly increased in individuals with LC (Extended Data Fig

Demetri GD, Benjamin RS, Blanke CD, Blay JY, Casali P, Choi H, et al

Biochem Soc Trans 12:3335 James EA, Gygi SP, Adams ML, Pierce RH, Fausto N, Aebersold RH, Nelson SD, Bruschi SA (2002) Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1, 1, 2, 2-tetrafluoroethyl)-l-cysteine

In the case described by Khan et al ., 12 however, statin cessation led to aminotransferase normalization without any further intervention, which is consistent with immune-mediated DILI secondary to statin administration

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