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A recent 2020 study revealed significant improvement in time in bed, total sleep time, self-perceived sleep quality, greater time in Stage 4 sleep, and reduced amount of light sleep for people with fibromyalgia treated with CBT [6]

Early vascular remodeling is an adaptive protective mechanism, and vascular remodeling during decompensation can promote the progression of atherosclerosis and the occurrence of complications

Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

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Compared with our previous case report, in this article the antioxidant therapy is significantly enhanced, in fact in all three cases new antioxidant substances have been added (L-carnitine, coenzyme Q-10, Boswellia) and specifically in cases 2 and 3, we increased the dosages of two substances (propolis from 600 to 700 mg and bilberry from 160 to 180 mg), and we also added other substances (vitamin C 50 mg + superoxide dismutase 11,000 IU), which allowed us to significantly reduce the dosage of vitamin E