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Fosnocht AQ, Lucerne KE, Ellis AS, Olimpo NA, Briand LA (2019) Adolescent social isolation increases cocaine seeking in male and female mice

Elevated LPS levels compromise intestinal barrier integrity by downregulating tight junction proteins ( e.g ., ZO-1, occludin), resulting in intestinal permeability (leaky gut)

For patients with more severe or refractory pain, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen reduce prostaglandin-mediated inflammation by inhibiting cyclooxygenase-1 and cyclooxygenase-2, key enzymes in producing PGE2 (Banaszewska et al., 2022)

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[DOI] [PubMed] [Google Scholar] 47.Yang C.J., Wang C.S., Hung J.Y., Huang H.W., Chia Y.C., Wang P.H., Weng C.F., Huang M.S