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In multiple human cancer cell lines, depletion of GGCT downregulated HIF-1 at the mRNA and protein levels

The poor clinical outcomes are largely attributed to the tumors intrinsic resistance to therapy, driven by factors such as blood-brain barrier (BBB) impermeability, cellular heterogeneity, and the persistence of glioma stem cells (GSCs)

Exp Neurol 241:122124

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