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It is widely expressed in the CNS (e.g., prefrontal cortex, substantia nigra, raphe nuclei, or hippocampus), PNS, and peripheral tissues (e.g., immune cells), indicating that KORs play an important role in the modulation of pain as well as regulating affective and emotional states [58]

AOD 9604 and Cartilage / Joint Research Interest in AOD 9604 later shifted toward cartilage repair and osteoarthritis models : In a collagenase-induced knee osteoarthritis (OA) rabbit model , weekly intra-articular injections of AOD 9604 (0.25 mg), with or without hyaluronic acid (HA), enhanced cartilage regeneration compared with saline controls

doi: 10.1016/j.neuroscience.2019.11.036

doi: 10.1007/s00296-017-3725-2

These messengers stimulate specific regions to increase natural processes than decreased due to aging, injuries or illnesses