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Cysteinyl-glycine dipeptide undergoes further breakdown by enzyme dipeptidase to produce free cysteine and glycine, and all three amino acids are taken up by cells and used to re-synthesize G-SH, a molecule that plays an important role in protecting cells from oxidative stress resulting from normal cell metabolism [19]

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Their subtle effects may influence risk for birth defects, cardiovascular disease, cancer, and neurodevelopmental conditions

The second way of assessing changes during the treatment period compared the measurements between the baseline and the last treatment visit (i.e., 24-week visit)

Ero1 can be oxidized rapidly in the presence of flavin adenine dinucleotide (FAD) and oxygen, indicating that oxygen is the ultimate electron acceptor (Tu & Weissman, 2002)