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Although the data on nave IgM + /IgD + B cell counts is limited to few patients, all ICF syndrome type 1 and Weidemann-Steiner syndrome patients show increased numbers of these cells ( Figure 6F ) (60, 126128, 154, 161)

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The concentration of paracetamol level was measured to exclude toxic paracetamol levels

This was evidenced clinically (autotomy absent [79]

The very limited IL-1 formation as reported in mice123,124 was also confirmed in APAP overdose patients111, suggesting that inflammasome activation and IL-1 formation are of limited importance for APAP-induced liver injury in mice and humans
