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doi: 10.2174/1381612043384655 37 ZhangPLiTWuXNiceECHuangCZhangY

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The inhibition of autophagy via Atg7 deletion, Atg5 knockdown, or pharmacological blockade precipitates a shift toward a pro-inflammatory phenotype, characterized by ameboid morphology and the overproduction of cytokines such as IL-1, IL-6, and TNF [103,104]