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A phase I study of the oral mTOR inhibitor ridaforolimus (RIDA) in combination with the IGF-1R antibody dalotozumab (DALO) in patients (pts) with advanced solid tumors

doi: 10.1038/nrc2562 35 WangCChenLHouXLiZKabraNMaYet al

56-58 While several factors, including exposure to environmental toxins, 56,59,60 also contribute to mitochondrial dysfunction in the substantia nigra , age-related mutations in mitochondrial DNA are thought to be a primary culprit

We will not discuss these clinical studies as there are already several reviews on the topic

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