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10.1146/annurev-pharmtox-010617-052735 Annu

Britten RA, Green JA, Warenius HM

Adherence to MIND diet, genetic susceptibility, and incident dementia in three US cohorts

A recent study highlighted the AGR2/IGF1 signaling loop as an example of tumorCAF crosstalk: PDAC cells secrete anterior gradient-2 (AGR2), which activates CAFs through the Wnt/-catenin pathway, causing the CAFs to upregulate and secrete insulin-like growth factor 1 (IGF-1)

Analysis of the IBM MarketScan research database The IBM MarketScan Commercial and Medicare Supplemental Databases from January 2017 to December 2019 were purchased from IBM Watson Health (Armonk, NY)
