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We also pay attention to selenium, a trace mineral that acts as a critical cofactor for glutathione peroxidase

Indeed, lowering TSH to this range has been associated with modest improvements in resting energy expenditure and reductions in fat mass in hypothyroid patients (33)

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Sikiric P, et al

Oxidative damage to mtDNA leads to a positive feedback loop in ROS production as the ETC enzymes encoded by mtDNA are damaged, impairing the ETC and increasing electron leakage (Rice et al., 2011