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The genetic association between the genes encoding methionine synthase and N5,10-methylenetetrahydrofolate reductase suggests a close relationship between these enzymes and the tetrahydrofolate metabolism (Figure 2) [14, 15, 16, 17]

Interestingly, the therapeutic effect was observed regardless of administration route and in both the liver and brain, two organs most susceptible to overproduction and accumulation of toxic porphyrins

[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Ba M., Long H., Yan Z., Wang S., Wu Y., Tu Y., Gong Y., Cui S

Patient selection criteria are not well-established, and determining which patients are most likely to benefit from these therapies requires clinical judgment based on limited evidence
