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J Biol Chem 282(19):1433714347 Han D, Canali R, Rettori D, Kaplowitz N (2003) Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria

However, ascorbic acid can also be a pro-oxidant in the presence of metals such as iron and copper triggered by Fentons reaction (Buettner, 1993

However, the detected deficits are in good agreement with the here observed hippocampal hypometabolism and synaptic alterations in the hippocampus of Tg4-42 mice 22

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