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Wnt signaling in stem cell regulation and tissue regeneration In contrast to the Wnt/Frizzled/-catenin axis, which is evolutionarily conserved from early multicellular animals and onward, the R-spondin/Lgr gene families are primarily a vertebrate specific evolutionary addition

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Int J Mol Sci 21:3688

More importantly, he made an astute observation in regards to the video at the bottom of the just mentioned Aljazeera link
