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Validated transport simulations demonstrate that this packaging architecture restricts moisture pickup to 0.2% across 30-day trans-equatorial air routes, with assay degradation confined below 0.5%-quantifiably ensuring that the material arriving at the CMO floor exhibits visual appearance, flow properties, and analytical profiles identical to the shipped Certificate of Analysis

This has important clinical consequences, such as the lack of biological markers [7] and the hindered development of targeted pharmacological treatments