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However, when using iron and copper chelators, careful control of dosage is necessary to avoid excessive chelation, which could lead to iron or copper deficiency and disrupt normal cellular physiological functions

Animal studies involving new monomeric peptides that have agonistic properties at more than a single site have been shown to reduce body weight and improve glycaemia by combining activity at GLP-1, glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptors [12]

In particular, cell types that normally have low G6PD expression in nondeficient individuals may be likely to succumb when faced with oxidant stress in deficient individuals where the G6PD expression is even lower than normal (39, 115) (Fig