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In addition, researchers also noted that microglial cells expressed HIF3A under inflammatory conditions, and hypoxia treatment resulted in a marked upregulation of HIF3A mRNA levels in the adult rat cortex, hippocampus, lungs, kidneys, and myocardial tissue (Torii et al., 2011

When the cancer cells break out of latency, they reinitiate overt outgrowth and overtake the local tissue microenvironment

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