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Erastin and RSL3, which are known as ferroptosis activators, lead to the buildup of CHMP5 and CHMP6 in the plasma membrane of pancreatic cancer cells, and the knocking out of CHMP5 or CHMP6 intensifies the susceptibility of cancer cells to ferroptosis

Caspase 1 is known to trigger inflammatory responses, whereas caspase 8 is implicated in regulating apoptosis and subsequent necrosis across various hepatic conditions

Together, these results suggest that the NLRP3 inflammasome is a potential intervention target for AD

6 The pathophysiology of mild TBI remains poorly understood due to the absence of diagnosis using standard clinical imaging, or other symptomatic measurements

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