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Moreover, a study of 52 cognitively healthy adults, averaging 70 years of age, revealed a positive correlation between greater melatonin levels 6 hours before habitual bedtime and hippocampal volume - a region susceptible to AD pathology and integral to memory function [224, 225]

Control studies Rats (n = 9 per group) were used to determine the effects of NLX (1.5 mg/kg, IV) that had received co-injections of vehicle (saline) rather than the co-injections of fentanyl (Supplemental Table 2)

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