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Nanodelivery of BA receptor modulatorssuch as the FXR agonist obeticholic acid (OCA) and the GPBAR1 antagonist 5-cholanic acid (5-CA)enhanced NK, NKT, and CD8+ T cell infiltration and triggered potent anti-tumor responses in liver cancer models (152)

To evaluate the role of GSTP in sepsis pathophysiology, we deleted the mouse Gstp gene cluster

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Notably, NLCs are the least toxic nanoparticle carriers when administered in vivo (Muller and Keck, 2004)