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Acknowledgments The authors thank Dimitry Lapage for his guidance on animal feeding experiment and Anneke Ovyn for her guidance on the parameter test in the laboratory

[DOI] [PubMed] [Google Scholar] 41.Clark J., Clore E.L., Zheng K., Adame A., Masliah E., Simon D.K

In these conditions, zinc is released in excess by presynaptic neurons and astrocytes, resulting in neuronal death via the activation of microglia, NADPH oxidase and the production of ROS in neurons [60,61,62]

In cells containing mitochondria, ALA is reduced in an NADH-dependent reaction with lipoamide dehydrogenase to form dihydrolipoic acid (DHLA), whereas in cells that lack mitochondria, ALA can instead be reduced to DHLA via NADPH with glutathione (GSH) and thioredoxin reductases (Jones et al., 1998
