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This review summarizes the evidence for targeting oxidative stress and inflammation in patients with COPD with mucolytic/antioxidant thiols and inhaled corticosteroids (ICS), either alone or in combination

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Simultaneously, the significant accumulation of ferrous iron ions (Fe + ) provides catalytic substrates for the Fenton reaction, further amplifying the oxidative stress

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The study enrolled 296 subjects across 10 European centers in 8 countries and followed them over 12 months

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2009;Appendix 4:Appendix 4I Simes RF, Ferro R, Silva MR, Pinho SLC, Ferreira L, Oliveira PJ, et al

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