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However, in AD, tau becomes hyperphosphorylated to detach from microtubules and form toxic neurofibrillary tangles that impair cellular transport and accelerate neuronal death (Ye et al., 2025)

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[15] In hepatocytes, compounds undergo enzymatic transformation in two main phases: Phase I reactions (often mediated by cytochrome P450 enzymes) introduce functional groups, and Phase II reactions conjugate these compounds to increase water solubility and facilitate elimination

Interestingly, the levels of glutathione and mitochondrial function, which were lower in older mice before taking GlyNAC, and oxidative stress, which was higher before GlyNAC, also were comparable to those found in younger mice after taking GlyNAC for six weeks