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These OH radicals can further abstract electrons from unsaturated fatty acids (FAs), creating unstable lipid radicals that initiate a self-propagating chain reaction of lipid peroxidation, ultimately leading to lysosomal membrane rupture and leakage [182]

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However, for several decades, LDL-C has been estimated from a standard lipid profile that includes measurements of total cholesterol, high-density lipoprotein cholesterol (HDL-C), and triglycerides using an equation proposed by James Friedewald in 1972 ( 6 )

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