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A specific product (Carni Q-Gel, Tishcon Corporation,Westbury, NY) containing 2250 mg of carnitine and 270 mg of coenzyme Q10 has been taken daily for 12 weeks

Behavioral strategies form the foundation: fixed wake times (more important than fixed bedtimes), morning bright light exposure for 30 minutes upon waking, evening light restriction and screen hygiene, and regularized meal times and exercise

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The mtDNA is more vulnerable to excessive ROS-related damage to biomolecules, such as DNA repair enzyme proteins, than nuclear DNA (112), which disrupts the ETC and ultimately induces dysregulation of mitochondrial OXPHOS (113)

Sensitivity analyses were conducted to determine the effect of carnitine dose, duration of carnitine therapy, age, patient population, and baseline values of each specific endpoint on the effect of carnitine on the endpoint