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revealed that chitosan-coated nanoemulsions were effective in delivering BNN27 (a synthetic C-17-spirodehydroepiandrosterone analogue) to the brain via intranasal administration, as the mucoadhesive properties of the chitosan increased the drug retention in the nasal passage and facilitated efficient brain disposition of the neurosteroid compared with liposomes (Kannavou et al., 2023)

The WD Association in the USA has recently celebrated its 40th year anniversary and the WD Support Group UK is approaching its silver (25-year) anniversary

303 The predictive relationship among DPDs also suggests that diabetic microangiopathy is not the only indicator of the risk for macroangiopathy, and that the various types of diabetic microangiopathy are also closely interrelated

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65 , 66 These programs are regulated by the chromatin state (accessibility for transcription factors), epigenetic mechanisms contributing to transcriptional output and LSC plasticity via activation or repression of gene expression