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A critical function of the intestinal epithelium is to form a barrier that prevents permeation of pro-inflammatory molecules, such as pathogens, toxins, and antigens, from the luminal environment into the mucosal tissues and circulatory system.1 Barrier defects have been associated with a variety of human diseases, including those primarily affecting the gut, such as IBD, celiac disease, and IBS, as well as systemic diseases or diseases involving other organ systems, such as type I diabetes, acquired immunodeficiency syndrome (AIDS), multiple sclerosis, and rheumatoid arthritis.2,3,4,5,6,7 Epithelial tight junctions (TJs) maintain the intestinal barrier while regulating permeability of ions, nutrients, and water

(1996) used cultures at 59 days in vitro

The primary function of GSTs is detoxifying different toxins (insecticides, herbicides, drugs) via catalyzing the conjugation to glutathione (GSH)

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Carbon 239 , 120280 (2025)