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456 In the spinal cord, the influx of neuropathic signals to the dorsal horn leads to central sensitization, characterized by increased spontaneous neuronal activity, lowered activation thresholds for peripheral stimuli, heightened responses to sub-threshold stimuli, and expansion of receptive fields

While trauma is believed to be the initial event, many theories have been proposed for the pathogenesis of Peyronies disease, including: auto-immune factors, excess production of chemicals (known as cytokines) in the tissue of the penis, and abnormalities of cell behavior

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