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Pro-inflammatory cytokines (IL-8, IL-12, IL-17, IL-18, and TNF) could stimulate miRNA-506 promoter activity in human cholangiocytes

Such ligand fishing has the potential to both give new insight into protein function in planta as well as identifying novel classes of natural product inhibitors of enzymes of biotechnological interest such as GSTs

When P r was calculated for the different substituents within the structures of interest, fragments with a tendency to form highly populated binding modes were identified, and hence, valuable substituent-interaction relationships could be determined

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