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It is class-wide counter-regulation: stopping removes the signal that was holding down a set-point the body still defends. The felt marker of the rebound is the return of food noise, which patients in the exit interviews reported as the first sign the loss was reversing. Metabolic loss tracks weight regain

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has consultancy agreements with Novartis and received honoraria for advisory boards with Novartis, Galderma, Napp, Sanofi, Eli Lilly and Janssen, which funded a recent Cardiff University Dermatology Life Quality Index (DLQI) research project, in which he is a joint inventor and receives royalties

The main theoretical benefit is synergy