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It is delivered to the tissues via chylomicron transport and then to the liver through chylomicron remnant uptake

Caldovic L, Tuchman M

Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

Detoxification of Endogenous Compounds and Xenobiotics GSH and GSH-related enzymes have a relevant role in cellular detoxification

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