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Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives

3, e174 (2005)

These markers include executionary caspases 9 and 3, which are activated to cleaved form, holding effector activity to downstream proteins, such as activation of PARP-1 (Poly[ADP-ribose] polymerase 1), whose downstream cleavage is linked to an increase in DNA fragmentation in the nucleus, triggering apoptosis in cells [133,136,137,138]

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